Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

Name: Anti-ABRAXAS2 Polyclonal Antibody
Brand: abinScience
SKU: HB533014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HB533014

Descripción

Anti-ABRAXAS2 Polyclonal Antibody (HB533014) is a rabbit polyclonal antibody detecting BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human ABRAXAS2 (Met1-Ile158).

Objetivo

BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

Q15018, Q3TCJ1, A6QLR3

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

BRISC complex subunit Abraxas 2 (ABRAXAS2) is a ~46 kDa protein. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression.

1. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193

2. Cooper, EM. et al. (2010) The Journal of biological chemistry 285, 10344-52. PMID: 20032457

3. Feng, L. et al. (2010) The Journal of biological chemistry 285, 30982-8. PMID: 20656690

4. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

5. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665

6. Zeqiraj, E. et al. (2015) Molecular cell 59, 970-83. PMID: 26344097

7. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-ABRAXAS2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

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Referencias

Datasheet

SDS