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| カタログ番号 | HB533014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABRAXAS2 Polyclonal Antibody (HB533014) is a rabbit polyclonal antibody detecting BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human ABRAXAS2 (Met1-Ile158). | ||||||||
| ターゲット | BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15018, Q3TCJ1, A6QLR3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | BRISC complex subunit Abraxas 2 (ABRAXAS2) is a ~46 kDa protein. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. 1. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193 2. Cooper, EM. et al. (2010) The Journal of biological chemistry 285, 10344-52. PMID: 20032457 3. Feng, L. et al. (2010) The Journal of biological chemistry 285, 30982-8. PMID: 20656690 4. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 5. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665 6. Zeqiraj, E. et al. (2015) Molecular cell 59, 970-83. PMID: 26344097 7. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148 | ||||||||
| 注意事項 | For research use only |
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