Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

Name: Anti-ABRAXAS2 Polyclonal Antibody
Brand: abinScience
SKU: HB533014
Price: 168 USD
Availability: InStock

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100ug

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Каталожный номер

HB533014

Описание

Anti-ABRAXAS2 Polyclonal Antibody (HB533014) is a rabbit polyclonal antibody detecting BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human ABRAXAS2 (Met1-Ile158).

Цель

BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q15018, Q3TCJ1, A6QLR3

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

BRISC complex subunit Abraxas 2 (ABRAXAS2) is a ~46 kDa protein. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression.

1. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193

2. Cooper, EM. et al. (2010) The Journal of biological chemistry 285, 10344-52. PMID: 20032457

3. Feng, L. et al. (2010) The Journal of biological chemistry 285, 30982-8. PMID: 20656690

4. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

5. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665

6. Zeqiraj, E. et al. (2015) Molecular cell 59, 970-83. PMID: 26344097

7. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-ABRAXAS2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

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Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

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