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| カタログ番号 | HW427014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ACAA2 Polyclonal Antibody (HW427014) is a rabbit polyclonal antibody detecting ACAA2 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Pongo abelii, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ACAA2 (Arg90-Ala397). | ||||||||
| ターゲット | Acetyl-CoA acyltransferase, Mitochondrial 3-oxoacyl-CoA thiolase, T1, Beta-ketothiolase, 3-ketoacyl-CoA thiolase, mitochondrial, Acyl-CoA hydrolase, mitochondrial, ACAA2, Acetyl-CoA acetyltransferase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P42765 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) is a ~41 kDa protein. In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). 1. Kiema, TR. et al. (2014) Acta crystallographica. Section D, Biological crystallography 70, 3212-25. PMID: 25478839 2. Cao, W. et al. (2008) Biochimica et biophysica acta 1780, 873-80. PMID: 18371312 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ACAA2 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Mouse heart lysate
Lane 2: Mouse liver lysate
Lane 3: Rat heart lysate
Lane 4: Rat liver lysate
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