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| カタログ番号 | HB808014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ACO1 Polyclonal Antibody (HB808014) is a rabbit polyclonal antibody detecting ACO1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human ACO1 (Lys26-Ile243). | ||||||||
| ターゲット | Cytoplasmic aconitate hydratase, Aconitase, EC:4.2.1.3, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P21399, P28271, Q63270 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytoplasmic aconitate hydratase (ACO1) is a ~98 kDa protein. Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA. 1. Haile, DJ. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 11735-9. PMID: 1281544 2. Kaptain, S. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 10109-13. PMID: 1946430 3. Philpott, CC. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 7321-5. PMID: 8041788 4. Stehling, O. et al. (2013) Cell metabolism 18, 187-98. PMID: 23891004 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-ACO1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: U2OS cell lysate
Lane 3: 293T cell lysate
Lane 4: HepG2 cell lysate
Lane 5: A549 cell lysate
Lane 6: Mouse liver lysate
Lane 7: Rat liver lysate
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