Anti-ACSL4 Polyclonal Antibody (HT115024)

Name: Anti-ACSL4 Polyclonal Antibody
Brand: abinScience
SKU: HT115024
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HT115024

Description

Anti-ACSL4 Polyclonal Antibody (HT115024) is a rabbit polyclonal antibody detecting ACSL4 in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human ACSL4 (Asp77-Ile262).

Cible

Long-chain-fatty-acid--CoA ligase 4, EC:6.2.1.3, Arachidonate--CoA ligase, EC:6.2.1.15, Long-chain acyl-CoA synthetase 4, LACS 4, ACSL4, ACS4, FACL4, LACS4

Niveau d'endotoxines

Please contact with the lab for this information.

Masse moléculaire observée

~80 kDa

Purification

Purified by antigen affinity column.

Numéro d'accès

O60488, O35547, Q9QUJ7

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Long-chain-fatty-acid--CoA ligase 4 (ACSL4) is a ~79 kDa protein. Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion.

1. Golej, DL. et al. (2011) Journal of lipid research 52, 782-93. PMID: 21242590

2. Nakahara, K. et al. (2012) Molecular cell 46, 461-71. PMID: 22633490

3. Ohkuni, A. et al. (2013) Biochemical and biophysical research communications 442, 195-201. PMID: 24269233

4. Shimbara-Matsubayashi, S. et al. (2019) Biological & pharmaceutical bulletin 42, 850-855. PMID: 31061331

5. Li, Z. et al. (2024) Nature chemical biology 20, 1341-1352. PMID: 38720107

6. Doll, S. et al. (2017) Nature chemical biology 13, 91-98. PMID: 27842070

7. Zhang, HL. et al. (2022) Nature cell biology 24, 88-98. PMID: 35027735

Note

For research use only

Images

Reférences

Fiche technique

Anti-ACSL4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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