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| カタログ番号 | HX034014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ACTB/β-actin/Beta Actin Polyclonal Antibody (HX034014) is a rabbit polyclonal antibody detecting Beta-actin in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human β-actin (Met1-Phe375). | ||||||||
| ターゲット | Beta-actin, ACTB, Actin, cytoplasmic 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P60709 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Actin, cytoplasmic 1 (ACTB/β-actin) is a ~41 kDa protein. Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. 1. Hundt, N. et al. (2014) The FEBS journal 281, 5279-91. PMID: 25255767 2. Drazic, A. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 4399-4404. PMID: 29581253 3. Schrank, BR. et al. (2018) Nature 559, 61-66. PMID: 29925947 4. Serna, M. et al. (2024) Developmental cell 59, 3175-3188.e8. PMID: 39321809 5. Aher, A. et al. (2024) Nature structural & molecular biology 31, 1124-1133. PMID: 38609661 | ||||||||
| 注意事項 | For research use only. |
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