中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HX989014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ADK Polyclonal Antibody (HX989014) is a rabbit polyclonal antibody detecting ADK in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Cricetulus griseus.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ADK (Ile94-Ala339). | ||||||||
| ターゲット | Adenosine 5'-phosphotransferase, ADK, AK, Adenosine kinase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P55263 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Adenosine kinase (ADK) is a ~40 kDa protein. Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL. 1. Bjursell, MK. et al. (2011) American journal of human genetics 89, 507-15. PMID: 21963049 2. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445 3. Palella, TD. et al. (1980) The Journal of biological chemistry 255, 5264-9. PMID: 6246102 4. Spychala, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 1232-7. PMID: 8577746 5. McNally, T. et al. (1997) Biochemical and biophysical research communications 231, 645-50. PMID: 9070863 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
