

| Каталожный номер | HX989014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-ADK Polyclonal Antibody (HX989014) is a rabbit polyclonal antibody detecting ADK in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Cricetulus griseus.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human ADK (Ile94-Ala339). | ||||||||
| Цель | Adenosine 5'-phosphotransferase, ADK, AK, Adenosine kinase | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P55263 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Adenosine kinase (ADK) is a ~40 kDa protein. Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL. 1. Bjursell, MK. et al. (2011) American journal of human genetics 89, 507-15. PMID: 21963049 2. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445 3. Palella, TD. et al. (1980) The Journal of biological chemistry 255, 5264-9. PMID: 6246102 4. Spychala, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 1232-7. PMID: 8577746 5. McNally, T. et al. (1997) Biochemical and biophysical research communications 231, 645-50. PMID: 9070863 | ||||||||
| Примечание | For research use only. |
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