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| カタログ番号 | HW676014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ADRA1A Polyclonal Antibody (HW676014) is a rabbit polyclonal antibody detecting ADRA1A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ADRA1A (Ser330-Val466). | ||||||||
| ターゲット | ADRA1C, ADRA1A, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, Alpha-1A adrenoceptor, Alpha-1A adrenergic receptor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35348 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Alpha-1A adrenergic receptor (ADRA1A) is a ~51 kDa protein. Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) protein. Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. 1. Su, M. et al. (2023) Nature communications 14, 4819. PMID: 37563160 2. Wright, CD. et al. (2008) Circulation research 103, 992-1000. PMID: 18802028 3. Schwinn, DA. et al. (1995) The Journal of pharmacology and experimental therapeutics 272, 134-42. PMID: 7815325 4. Weinberg, DH. et al. (1994) Biochemical and biophysical research communications 201, 1296-304. PMID: 8024574 5. Forray, C. et al. (1994) Molecular pharmacology 45, 703-8. PMID: 8183249 6. Shibata, K. et al. (1996) British journal of pharmacology 118, 1403-8. PMID: 8832064 7. Wright, CD. et al. (2012) Cellular signalling 24, 794-802. PMID: 22120526 8. Ogata, T. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 3811-6. PMID: 24567387 | ||||||||
| 注意事項 | For research use only. |
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