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| カタログ番号 | MY357014 | ||||||||
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| 説明 |
Anti-ADRB2 Polyclonal Antibody (MY357014) is a rabbit polyclonal antibody detecting Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Adrb2; Adrb2r in ELISA, IHC, WB. Suitable for Rat and Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant mouse ADRB2 (Pro330-Leu418). | ||||||||
| ターゲット | Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Adrb2; Adrb2r | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P18762, P10608 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Beta-2 adrenergic receptor (ADRB2) is a ~46 kDa protein. G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways. ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively. Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate. Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway. 1. Zhu, WZ. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 1607-12. PMID: 11171998 2. Wang, Y. et al. (2008) The Journal of biological chemistry 283, 1799-807. PMID: 18056263 3. Allen, JM. et al. (1988) The EMBO journal 7, 133-8. PMID: 2834198 | ||||||||
| 注意事項 | For research use only |
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