Anti-AHR Polyclonal Antibody (HW686014)

Name: Anti-AHR Polyclonal Antibody
Brand: abinScience
SKU: HW686014
Price: 168 USD
Availability: InStock

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50ug
100ug

Número:

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Número de catálogo

HW686014

Descripción

Anti-AHR Polyclonal Antibody (HW686014) is a rabbit polyclonal antibody detecting AhR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Mus caroli, and Mouse castaneus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human AHR (Val23-Gln273).

Objetivo

bHLHe76, AhR, Ah receptor, AHR, Aryl hydrocarbon receptor, Class E basic helix-loop-helix protein 76, BHLHE76

Purificación

Purified by antigen affinity column.

Número de acceso

P35869

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Aryl hydrocarbon receptor (AHR) is a ~96 kDa protein. Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.

1. MacPherson, L. et al. (2013) Nucleic acids research 41, 1604-21. PMID: 23275542

2. Gomez, A. et al. (2018) The Biochemical journal 475, 3827-3846. PMID: 30373764

3. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467

4. Ema, M. et al. (1994) The Journal of biological chemistry 269, 27337-43. PMID: 7961644

5. Puga, A. et al. (2002) Chemico-biological interactions 141, 117-30. PMID: 12213388

6. Borovok, N. et al. (2020) Frontiers in genetics 11, 582796. PMID: 33193710

7. Haidar, R. et al. (2021) Scientific reports 11, 18194. PMID: 34521881

9. Zhang, X. et al. (2020) Journal of agricultural and food chemistry 68, 10678-10684. PMID: 32866000

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-AHR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-AHR Polyclonal Antibody (HW686014)

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Referencias

Datasheet

SDS