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| カタログ番号 | HW686014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-AHR Polyclonal Antibody (HW686014) is a rabbit polyclonal antibody detecting AhR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Mus caroli, and Mouse castaneus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AHR (Val23-Gln273). | ||||||||
| ターゲット | bHLHe76, AhR, Ah receptor, AHR, Aryl hydrocarbon receptor, Class E basic helix-loop-helix protein 76, BHLHE76 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35869 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Aryl hydrocarbon receptor (AHR) is a ~96 kDa protein. Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. 1. MacPherson, L. et al. (2013) Nucleic acids research 41, 1604-21. PMID: 23275542 2. Gomez, A. et al. (2018) The Biochemical journal 475, 3827-3846. PMID: 30373764 3. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467 4. Ema, M. et al. (1994) The Journal of biological chemistry 269, 27337-43. PMID: 7961644 5. Puga, A. et al. (2002) Chemico-biological interactions 141, 117-30. PMID: 12213388 6. Borovok, N. et al. (2020) Frontiers in genetics 11, 582796. PMID: 33193710 7. Haidar, R. et al. (2021) Scientific reports 11, 18194. PMID: 34521881 9. Zhang, X. et al. (2020) Journal of agricultural and food chemistry 68, 10678-10684. PMID: 32866000 | ||||||||
| 注意事項 | For research use only. |
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