Anti-AHR Polyclonal Antibody (HW686014)

Name: Anti-AHR Polyclonal Antibody
Brand: abinScience
SKU: HW686014
Price: 168 USD
Availability: InStock

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Каталожный номер

HW686014

Описание

Anti-AHR Polyclonal Antibody (HW686014) is a rabbit polyclonal antibody detecting AhR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Mus caroli, and Mouse castaneus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human AHR (Val23-Gln273).

Цель

bHLHe76, AhR, Ah receptor, AHR, Aryl hydrocarbon receptor, Class E basic helix-loop-helix protein 76, BHLHE76

Очистка

Purified by antigen affinity column.

Номер доступа

P35869

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Aryl hydrocarbon receptor (AHR) is a ~96 kDa protein. Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons.

1. MacPherson, L. et al. (2013) Nucleic acids research 41, 1604-21. PMID: 23275542

2. Gomez, A. et al. (2018) The Biochemical journal 475, 3827-3846. PMID: 30373764

3. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467

4. Ema, M. et al. (1994) The Journal of biological chemistry 269, 27337-43. PMID: 7961644

5. Puga, A. et al. (2002) Chemico-biological interactions 141, 117-30. PMID: 12213388

6. Borovok, N. et al. (2020) Frontiers in genetics 11, 582796. PMID: 33193710

7. Haidar, R. et al. (2021) Scientific reports 11, 18194. PMID: 34521881

9. Zhang, X. et al. (2020) Journal of agricultural and food chemistry 68, 10678-10684. PMID: 32866000

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-AHR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-AHR Polyclonal Antibody (HW686014)

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