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Anti-AICDA Polyclonal Antibody (HV754014)

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Vista general
Número de catálogoHV754014
Descripción
Anti-AICDA Polyclonal Antibody (HV754014) is a rabbit polyclonal antibody detecting AICDA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human AICDA (Gly23-Leu183).
Objetivo Single-stranded DNA cytosine deaminase, AICDA, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase
Purificación Purified by antigen affinity column.
Número de acceso Q9GZX7
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Single-stranded DNA cytosine deaminase (AICDA) is a ~23 kDa protein. Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

1. Conticello, SG. et al. (2008) Molecular cell 31, 474-484. PMID: 18722174
2. Ganesh, K. et al. (2011) The Journal of biological chemistry 286, 17091-102. PMID: 21385873
3. Okazaki, IM. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7920-5. PMID: 21518874
4. Ouadani, H. et al. (2016) Molecular immunology 79, 77-82. PMID: 27716525
5. Guo, JU. et al. (2011) Cell 145, 423-34. PMID: 21496894
Nota For research use only.
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-AICDA Polyclonal Antibody

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