Anti-AICDA Polyclonal Antibody (HV754014)

Name: Anti-AICDA Polyclonal Antibody
Brand: abinScience
SKU: HV754014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HV754014

Description

Anti-AICDA Polyclonal Antibody (HV754014) is a rabbit polyclonal antibody detecting AICDA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human AICDA (Gly23-Leu183).

Cible

Single-stranded DNA cytosine deaminase, AICDA, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9GZX7

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Single-stranded DNA cytosine deaminase (AICDA) is a ~23 kDa protein. Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

1. Conticello, SG. et al. (2008) Molecular cell 31, 474-484. PMID: 18722174

2. Ganesh, K. et al. (2011) The Journal of biological chemistry 286, 17091-102. PMID: 21385873

3. Okazaki, IM. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 7920-5. PMID: 21518874

4. Ouadani, H. et al. (2016) Molecular immunology 79, 77-82. PMID: 27716525

5. Guo, JU. et al. (2011) Cell 145, 423-34. PMID: 21496894

Note

For research use only.

Images

Reférences

Fiche technique

Anti-AICDA Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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