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Anti-AIFM1/AIF Polyclonal Antibody (HF658014)

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Número de catálogoHF658014
Descripción
Anti-AIFM1/AIF Polyclonal Antibody (HF658014) is a rabbit polyclonal antibody detecting AIFM1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human AIFM1/AIF (Leu102-Asp613).
Objetivo AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial
Purificación Purified by antigen affinity column.
Número de acceso O95831
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Apoptosis-inducing factor 1, mitochondrial (AIFM1/AIF) is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA.

1. Kim, JT. et al. (2006) FEBS letters 580, 6375-83. PMID: 17094969
2. Ghezzi, D. et al. (2010) American journal of human genetics 86, 639-49. PMID: 20362274
3. Rinaldi, C. et al. (2012) American journal of human genetics 91, 1095-102. PMID: 23217327
4. Mashimo, M. et al. (2021) The Journal of biological chemistry 296, 100046. PMID: 33168626
5. Sevrioukova, IF. (2016) Journal of molecular biology 428, 3650-65. PMID: 27178839
6. Son, YO. et al. (2009) Apoptosis : an international journal on programmed cell death 14, 796-808. PMID: 19418225
7. Hangen, E. et al. (2015) Molecular cell 58, 1001-14. PMID: 26004228
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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