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| カタログ番号 | HF658014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-AIFM1/AIF Polyclonal Antibody (HF658014) is a rabbit polyclonal antibody detecting AIFM1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AIFM1/AIF (Leu102-Asp613). | ||||||||
| ターゲット | AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95831 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Apoptosis-inducing factor 1, mitochondrial (AIFM1/AIF) is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. 1. Kim, JT. et al. (2006) FEBS letters 580, 6375-83. PMID: 17094969 2. Ghezzi, D. et al. (2010) American journal of human genetics 86, 639-49. PMID: 20362274 3. Rinaldi, C. et al. (2012) American journal of human genetics 91, 1095-102. PMID: 23217327 4. Mashimo, M. et al. (2021) The Journal of biological chemistry 296, 100046. PMID: 33168626 5. Sevrioukova, IF. (2016) Journal of molecular biology 428, 3650-65. PMID: 27178839 6. Son, YO. et al. (2009) Apoptosis : an international journal on programmed cell death 14, 796-808. PMID: 19418225 7. Hangen, E. et al. (2015) Molecular cell 58, 1001-14. PMID: 26004228 | ||||||||
| 注意事項 | For research use only. |
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