Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014)

Name: Anti-AIFM2/FSP1 Polyclonal Antibody
Brand: abinScience
SKU: HC098014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HC098014

Description

Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014) is a rabbit polyclonal antibody detecting AIFM2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant AIFM2/FSP1 (Met1-Pro373).

Cible

Ferroptosis suppressor protein 1, FSP1, EC:1.6.5.-, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, AMID, p53-responsive gene 3 protein, AIFM2, AMID, PRG3

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9BRQ8, Q8BUE4, A5PJM4

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ferroptosis suppressor protein 1 (AIFM2/FSP1) is a ~40 kDa protein. A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms.

1. Doll, S. et al. (2019) Nature 575, 693-698. PMID: 31634899

2. Bersuker, K. et al. (2019) Nature 575, 688-692. PMID: 31634900

3. Mishima, E. et al. (2022) Nature 608, 778-783. PMID: 35922516

4. Jin, DY. et al. (2023) Nature communications 14, 828. PMID: 36788244

5. Nakamura, T. et al. (2023) Nature structural & molecular biology 30, 1806-1815. PMID: 37957306

6. Li, W. et al. (2025) The EMBO journal 44, 1641-1662. PMID: 39881208

7. Zhang, S. et al. (2023) Cell research 33, 967-970. PMID: 37739993

8. Lan, H. et al. (2024) Cell discovery 10, 88. PMID: 39160155

9. Feng, S. et al. (2024) MedComm 5, e479. PMID: 38414669

10. Yang, JS. et al. (2025) Cell 188, 2569-2585.e20. PMID: 40233740

Note

For research use only

Images

Reférences

Fiche technique

Anti-AIFM2/FSP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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