Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014)

Name: Anti-AIFM2/FSP1 Polyclonal Antibody
Brand: abinScience
SKU: HC098014
Price: 168 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

HC098014

Описание

Anti-AIFM2/FSP1 Polyclonal Antibody (HC098014) is a rabbit polyclonal antibody detecting AIFM2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant AIFM2/FSP1 (Met1-Pro373).

Цель

Ferroptosis suppressor protein 1, FSP1, EC:1.6.5.-, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, AMID, p53-responsive gene 3 protein, AIFM2, AMID, PRG3

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q9BRQ8, Q8BUE4, A5PJM4

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Ferroptosis suppressor protein 1 (AIFM2/FSP1) is a ~40 kDa protein. A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms.

1. Doll, S. et al. (2019) Nature 575, 693-698. PMID: 31634899

2. Bersuker, K. et al. (2019) Nature 575, 688-692. PMID: 31634900

3. Mishima, E. et al. (2022) Nature 608, 778-783. PMID: 35922516

4. Jin, DY. et al. (2023) Nature communications 14, 828. PMID: 36788244

5. Nakamura, T. et al. (2023) Nature structural & molecular biology 30, 1806-1815. PMID: 37957306

6. Li, W. et al. (2025) The EMBO journal 44, 1641-1662. PMID: 39881208

7. Zhang, S. et al. (2023) Cell research 33, 967-970. PMID: 37739993

8. Lan, H. et al. (2024) Cell discovery 10, 88. PMID: 39160155

9. Feng, S. et al. (2024) MedComm 5, e479. PMID: 38414669

10. Yang, JS. et al. (2025) Cell 188, 2569-2585.e20. PMID: 40233740

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-AIFM2/FSP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

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