Anti-ALDH1A1 Polyclonal Antibody (HF669014)

Name: Anti-ALDH1A1 Polyclonal Antibody
Brand: abinScience
SKU: HF669014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HF669014

Description

Anti-ALDH1A1 Polyclonal Antibody (HF669014) is a rabbit polyclonal antibody detecting ALDH1A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ALDH1A1 (Met1-Ser501).

Cible

Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, ALDH-E1, RalDH1, Aldehyde dehydrogenase family 1 member A1, ALDH1A1, ALDH1, RALDH 1, ALDC, ALHDII, PUMB1

Purification

Purified by antigen affinity column.

Numéro d'accès

P00352

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Aldehyde dehydrogenase 1A1 (ALDH1A1) is a ~54 kDa protein. Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification.

1. Manzer, R. et al. (2003) DNA and cell biology 22, 329-38. PMID: 12941160

2. Choudhary, S. et al. (2005) Investigative ophthalmology & visual science 46, 259-67. PMID: 15623782

3. Collard, F. et al. (2007) Biochimie 89, 369-73. PMID: 17175089

4. Xiao, T. et al. (2009) Journal of toxicology and environmental health. Part A 72, 577-84. PMID: 19296407

5. Morgan, CA. et al. (2015) Chemico-biological interactions 234, 29-37. PMID: 25450233

6. Koch, MF. et al. (2015) Angewandte Chemie (International ed. in English) 54, 13550-4. PMID: 26373694

Note

For research use only.

Images

Reférences

Fiche technique

Anti-ALDH1A1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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