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| カタログ番号 | HF669014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ALDH1A1 Polyclonal Antibody (HF669014) is a rabbit polyclonal antibody detecting ALDH1A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ALDH1A1 (Met1-Ser501). | ||||||||
| ターゲット | Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, ALDH-E1, RalDH1, Aldehyde dehydrogenase family 1 member A1, ALDH1A1, ALDH1, RALDH 1, ALDC, ALHDII, PUMB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P00352 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Aldehyde dehydrogenase 1A1 (ALDH1A1) is a ~54 kDa protein. Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. 1. Manzer, R. et al. (2003) DNA and cell biology 22, 329-38. PMID: 12941160 2. Choudhary, S. et al. (2005) Investigative ophthalmology & visual science 46, 259-67. PMID: 15623782 3. Collard, F. et al. (2007) Biochimie 89, 369-73. PMID: 17175089 4. Xiao, T. et al. (2009) Journal of toxicology and environmental health. Part A 72, 577-84. PMID: 19296407 5. Morgan, CA. et al. (2015) Chemico-biological interactions 234, 29-37. PMID: 25450233 6. Koch, MF. et al. (2015) Angewandte Chemie (International ed. in English) 54, 13550-4. PMID: 26373694 | ||||||||
| 注意事項 | For research use only. |
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