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| カタログ番号 | HB614014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ALOX15 Polyclonal Antibody (HB614014) is a rabbit polyclonal antibody detecting ALOX15 in ELISA, IHC, WB. Suitable for Human, Bovine, Pongo abelii, and Pig.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ALOX15 (Lys170-Leu312). | ||||||||
| ターゲット | Arachidonate omega-6 lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, Hepoxilin A3 synthase Alox15, 12-LOX, 15-LOX-1, 15-LOX, Arachidonate 15-lipoxygenase, Polyunsaturated fatty acid lipoxygenase ALOX15, 12/15-lipoxygenase, Linoleate 13S-lipoxygenase, LOG15, ALOX15 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P16050 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Polyunsaturated fatty acid lipoxygenase ALOX15 is a ~74 kDa protein. Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE. It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties. Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. 1. Andersson, E. et al. (2006) Biochimica et biophysica acta 1761, 1498-505. PMID: 17052953 2. Sloane, DL. et al. (1991) Nature 354, 149-52. PMID: 1944593 3. Horn, T. et al. (2013) Redox biology 1, 566-77. PMID: 24282679 4. Teder, T. et al. (2014) Journal of lipid research 55, 2587-96. PMID: 25293588 5. Perry, SC. et al. (2020) Journal of lipid research 61, 1087-1103. PMID: 32404334 6. Kühn, H. et al. (1993) Biochimica et biophysica acta 1169, 80-9. PMID: 8334154 | ||||||||
| 注意事項 | For research use only. |
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