Anti-MIS/AMH Recombinant Antibody (SAA2666) (HY076023)

Name: Anti-MIS/AMH Recombinant Antibody (SAA2666)
Brand: abinScience
SKU: HY076023
Price: 191 USD
Availability: InStock

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1mg

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Número de catálogo	HY076023
Reactividad de especies	Human, Mouse
Aplicaciones	ELISA, IHC, WB
Especie huésped	Rabbit
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	SAA2666
Objetivo	AMH, Anti-Muellerian hormone, MIF, MIS, Muellerian-inhibiting factor, Muellerian-inhibiting substance
Nivel de endotoxinas	<10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P03971
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Anti-Muellerian hormone (AMH) is a ~59 kDa protein. The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions. Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction. Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation. In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Also plays a role in Leydig cell differentiation and function. 1. Weenen, C. et al. (2004) Molecular human reproduction 10, 77-83. PMID: 14742691 2. Hart, KN. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155118 3. Cate, RL. et al. (1986) Cell 45, 685-98. PMID: 3754790 4. Wilson, CA. et al. (1993) Molecular endocrinology (Baltimore, Md.) 7, 247-57. PMID: 8469238 5. di Clemente, N. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 2193-206. PMID: 20861221
Nota	For research use only