Anti-Human MIS/AMH Polyclonal Antibody (HY076014)

Name: Anti-Human MIS/AMH Polyclonal Antibody
Brand: abinScience
SKU: HY076014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HY076014

Описание

Anti-AMH Polyclonal Antibody (HY076014) is a rabbit polyclonal antibody detecting AMH in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human AMH (Ala453-Arg560).

Цель

MIF, AMH, Muellerian-inhibiting factor, Muellerian-inhibiting substance, MIS, Anti-Muellerian hormone

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

P03971

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Anti-Muellerian hormone (AMH) is a ~59 kDa protein. The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions. Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction. Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation. In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Also plays a role in Leydig cell differentiation and function.

1. Weenen, C. et al. (2004) Molecular human reproduction 10, 77-83. PMID: 14742691

2. Hart, KN. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155118

3. Cate, RL. et al. (1986) Cell 45, 685-98. PMID: 3754790

4. Wilson, CA. et al. (1993) Molecular endocrinology (Baltimore, Md.) 7, 247-57. PMID: 8469238

5. di Clemente, N. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 2193-206. PMID: 20861221

Примечание

For research use only.

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