Anti-ANXA2 Polyclonal Antibody (HY297014)

Name: Anti-ANXA2 Polyclonal Antibody
Brand: abinScience
SKU: HY297014
Price: 96 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HY297014

説明

Anti-ANXA2 Polyclonal Antibody (HY297014) is a rabbit polyclonal antibody detecting ANXA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human ANXA2 (Met1-Asp339).

ターゲット

Lipocortin II, Annexin A2, Calpactin-1 heavy chain, PAP-IV, p36, CAL1H, Calpactin I heavy chain, ANX2, ANX2L4, Protein I, Annexin-2, LPC2D, Annexin II, ANXA2, Placental anticoagulant protein IV, Chromobindin-8

精製

Purified by antigen affinity column.

アクセッション番号

P07355

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Annexin A2 (ANXA2) is a ~38 kDa protein. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation.

1. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458

2. Seidah, NG. et al. (2012) PloS one 7, e41865. PMID: 22848640

3. Ly, K. et al. (2014) The Journal of biological chemistry 289, 17732-46. PMID: 24808179

注意事項

For research use only.

イメージ

Western blot

Western blot analysis was performed using anti-ANXA2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: A431 cell lysate
Lane 3: A549 cell lysate
Lane 4: PC-12 cell lysate