Anti-ANXA2 Polyclonal Antibody (HY297014)

Name: Anti-ANXA2 Polyclonal Antibody
Brand: abinScience
SKU: HY297014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HY297014

Описание

Anti-ANXA2 Polyclonal Antibody (HY297014) is a rabbit polyclonal antibody detecting ANXA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human ANXA2 (Met1-Asp339).

Цель

Lipocortin II, Annexin A2, Calpactin-1 heavy chain, PAP-IV, p36, CAL1H, Calpactin I heavy chain, ANX2, ANX2L4, Protein I, Annexin-2, LPC2D, Annexin II, ANXA2, Placental anticoagulant protein IV, Chromobindin-8

Очистка

Purified by antigen affinity column.

Номер доступа

P07355

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Annexin A2 (ANXA2) is a ~38 kDa protein. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation.

1. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458

2. Seidah, NG. et al. (2012) PloS one 7, e41865. PMID: 22848640

3. Ly, K. et al. (2014) The Journal of biological chemistry 289, 17732-46. PMID: 24808179

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-ANXA2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: A431 cell lysate
Lane 3: A549 cell lysate
Lane 4: PC-12 cell lysate