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| カタログ番号 | HV707014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-AP2M1 Polyclonal Antibody (HV707014) is a rabbit polyclonal antibody detecting AP2M1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AP2M1 (Arg170-Cys435). | ||||||||
| ターゲット | Adaptor-related protein complex 2 subunit mu, AP-2 mu chain, CLAPM1, HA2 50 kDa subunit, Plasma membrane adaptor AP-2 50 kDa protein, Adaptin-mu2, AP2M1, KIAA0109, Clathrin coat assembly protein AP50, Adaptor protein complex AP-2 subunit mu, Clathrin assembly protein complex 2 mu medium chain, AP-2 complex subunit mu, Clathrin coat-associated protein AP50 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96CW1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | AP-2 complex subunit mu (AP2M1) is a ~49 kDa protein. Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. 1. Fraile-Ramos, A. et al. (2003) Traffic (Copenhagen, Denmark) 4, 243-53. PMID: 12694563 2. Motley, A. et al. (2003) The Journal of cell biology 162, 909-18. PMID: 12952941 3. Nakatsu, F. et al. (2003) Cell structure and function 28, 419-29. PMID: 14745134 4. Huang, F. et al. (2004) The Journal of biological chemistry 279, 16657-61. PMID: 14985334 5. Owen, DJ. et al. (2004) Annual review of cell and developmental biology 20, 153-91. PMID: 15473838 6. Helbig, I. et al. (2019) American journal of human genetics 104, 1060-1072. PMID: 31104773 9. Marcello, E. et al. (2013) The Journal of clinical investigation 123, 2523-38. PMID: 23676497 | ||||||||
| 注意事項 | For research use only. |
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