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| カタログ番号 | MV404014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Apelin/APLN Polyclonal Antibody (MV404014) is a rabbit polyclonal antibody detecting Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel in ELISA, IHC, WB. Suitable for Rat and Mouse.
Highlights
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| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant mouse Apelin/APLN (Val23-Phe77). | ||||||||
| ターゲット | Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9R0R3, Q9R0R4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Apelin (APLN) is a ~8 kDa protein. Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions. 1. Kawamata, Y. et al. (2001) Biochimica et biophysica acta 1538, 162-71. PMID: 11336787 2. Reaux, A. et al. (2001) Journal of neurochemistry 77, 1085-96. PMID: 11359874 3. Perjés, Á. et al. (2016) Basic research in cardiology 111, 2. PMID: 26611206 4. Lee, DK. et al. (2000) Journal of neurochemistry 74, 34-41. PMID: 10617103 | ||||||||
| 注意事項 | For research use only |
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