

| Каталожный номер | MV404014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Apelin/APLN Polyclonal Antibody (MV404014) is a rabbit polyclonal antibody detecting Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel in ELISA, IHC, WB. Suitable for Rat and Mouse.
Highlights
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| Реактивность видов | Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant mouse Apelin/APLN (Val23-Phe77). | ||||||||
| Цель | Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9R0R3, Q9R0R4 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Apelin (APLN) is a ~8 kDa protein. Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions. 1. Kawamata, Y. et al. (2001) Biochimica et biophysica acta 1538, 162-71. PMID: 11336787 2. Reaux, A. et al. (2001) Journal of neurochemistry 77, 1085-96. PMID: 11359874 3. Perjés, Á. et al. (2016) Basic research in cardiology 111, 2. PMID: 26611206 4. Lee, DK. et al. (2000) Journal of neurochemistry 74, 34-41. PMID: 10617103 | ||||||||
| Примечание | For research use only |
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