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Anti-APPL1 Polyclonal Antibody (HV723014)

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Vista general
Número de catálogoHV723014
Descripción
Anti-APPL1 Polyclonal Antibody (HV723014) is a rabbit polyclonal antibody detecting APPL1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human APPL1 (Phe404-Ser673).
Objetivo APPL1, Dip13-alpha, APPL, DIP13A, DCC-interacting protein 13-alpha, KIAA1428, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
Purificación Purified by antigen affinity column.
Número de acceso Q9UKG1
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

DCC-interacting protein 13-alpha (APPL1) is a ~79 kDa protein. Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages.

1. Mitsuuchi, Y. et al. (1999) Oncogene 18, 4891-8. PMID: 10490823
2. Miaczynska, M. et al. (2004) Cell 116, 445-56. PMID: 15016378
3. Wang, C. et al. (2009) The Journal of biological chemistry 284, 31608-15. PMID: 19661063
4. Prudente, S. et al. (2015) American journal of human genetics 97, 177-85. PMID: 26073777
5. Song, J. et al. (2016) Oncotarget 7, 279-92. PMID: 26583432
6. Cheng, KK. et al. (2014) Diabetes 63, 3748-58. PMID: 24879834
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-APPL1 Polyclonal Antibody

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