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| カタログ番号 | HV723014 | ||||||||
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| 説明 |
Anti-APPL1 Polyclonal Antibody (HV723014) is a rabbit polyclonal antibody detecting APPL1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human APPL1 (Phe404-Ser673). | ||||||||
| ターゲット | APPL1, Dip13-alpha, APPL, DIP13A, DCC-interacting protein 13-alpha, KIAA1428, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UKG1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DCC-interacting protein 13-alpha (APPL1) is a ~79 kDa protein. Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages. 1. Mitsuuchi, Y. et al. (1999) Oncogene 18, 4891-8. PMID: 10490823 2. Miaczynska, M. et al. (2004) Cell 116, 445-56. PMID: 15016378 3. Wang, C. et al. (2009) The Journal of biological chemistry 284, 31608-15. PMID: 19661063 4. Prudente, S. et al. (2015) American journal of human genetics 97, 177-85. PMID: 26073777 5. Song, J. et al. (2016) Oncotarget 7, 279-92. PMID: 26583432 6. Cheng, KK. et al. (2014) Diabetes 63, 3748-58. PMID: 24879834 | ||||||||
| 注意事項 | For research use only. |
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