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| カタログ番号 | HY315014 | ||||||||
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| 説明 |
Anti-AR Polyclonal Antibody (HY315014) is a rabbit polyclonal antibody detecting AR in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Crocuta crocuta.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AR (Leu660-Thr919). | ||||||||
| ターゲット | Dihydrotestosterone receptor, NR3C4, DHTR, Androgen receptor, AR, Nuclear receptor subfamily 3 group C member 4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P10275 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Androgen receptor (AR) is a ~99 kDa protein. Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. 1. Yang, J. et al. (2009) Endocrine-related cancer 16, 139-53. PMID: 19022849 2. Cui, J. et al. (2011) Cellular and molecular life sciences : CMLS 68, 1091-103. PMID: 20812024 | ||||||||
| 注意事項 | For research use only. |
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