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| カタログ番号 | HA647014 | ||||||||
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| 説明 |
Anti-ARFIP1 Polyclonal Antibody (HA647014) is a rabbit polyclonal antibody detecting Arfaptin-1; ADP-ribosylation factor-interacting protein 1; ARFIP1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human ARFIP1 (Ile117-Gln373). | ||||||||
| ターゲット | Arfaptin-1; ADP-ribosylation factor-interacting protein 1; ARFIP1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P53367, G5E8V9, Q9JHU5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Arfaptin-1 (ARFIP1) is a ~41 kDa protein. Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. 1. Gehart, H. et al. (2012) Developmental cell 23, 756-68. PMID: 22981988 2. Kanoh, H. et al. (1997) The Journal of biological chemistry 272, 5421-9. PMID: 9038142 | ||||||||
| 注意事項 | For research use only |
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