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| カタログ番号 | HC083014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ARL8B Polyclonal Antibody (HC083014) is a rabbit polyclonal antibody detecting ARL8B in ELISA, IHC, WB. Suitable for Human, Rat, Mouse, Bovine, and Zebrafish.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ARL8B (Met1-Ser186). | ||||||||
| ターゲット | ADP-ribosylation factor-like protein 8B, EC:3.6.5.2, ADP-ribosylation factor-like protein 10C, Novel small G protein indispensable for equal chromosome segregation 1, ARL8B, ARL10C, GIE1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NVJ2, Q66HA6, Q9CQW2, Q2KI07, Q6NZW8, Q5ZKQ8, Q96BM9, Q8VEH3, Q9VHV5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ADP-ribosylation factor-like protein 8B is a ~21 kDa protein. Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. 1. Okai, T. et al. (2004) Journal of cell science 117, 4705-15. PMID: 15331635 2. Hofmann, I. et al. (2006) Journal of cell science 119, 1494-503. PMID: 16537643 3. Bagshaw, RD. et al. (2006) Biochemical and biophysical research communications 344, 1186-91. PMID: 16650381 4. Pu, J. et al. (2015) Developmental cell 33, 176-88. PMID: 25898167 5. Deshar, R. et al. (2016) The FEBS journal 283, 4583-4599. PMID: 27808481 6. Marwaha, R. et al. (2017) The Journal of cell biology 216, 1051-1070. PMID: 28325809 7. Rosa-Ferreira, C. et al. (2011) Developmental cell 21, 1171-8. PMID: 22172677 8. Tuli, A. et al. (2013) Molecular biology of the cell 24, 3721-35. PMID: 24088571 9. Michelet, X. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 3160-3169. PMID: 29592961 10. Garg, S. et al. (2011) Immunity 35, 182-93. PMID: 21802320 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-ARF1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: SKOV3 cell lysate
Lane 3: DU145 cell lysate
Lane 4: HepG2 cell lysate
Lane 5: Lncap cell lysate
Lane 6: 293T cell lysate
Lane 7: Mouse brain lysate
Lane 8: Mouse spleen lysate
Lane 9: Mouse lung lysate
Lane 10: Rat brain lysate
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