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Anti-ARRB1 Polyclonal Antibody (HW793014)

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Aperçu
Numéro de catalogueHW793014
Description
Anti-ARRB1 Polyclonal Antibody (HW793014) is a rabbit polyclonal antibody detecting ARRB1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human ARRB1 (Asp3-Thr246).
Cible ARRB1, Beta-arrestin-1, Non-visual arrestin-2, ARR1, Arrestin beta-1
Purification Purified by antigen affinity column.
Numéro d'accès P49407
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Beta-arrestin-1 (ARRB1) is a ~47 kDa protein. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.

1. Maharana, J. et al. (2023) Molecular cell 83, 2091-2107.e7. PMID: 37209686
2. Maharana, J. et al. (2024) Science (New York, N.Y.) 383, 101-108. PMID: 38175886
3. Puca, L. et al. (2013) Journal of cell science 126, 4457-68. PMID: 23886940
4. Lin, J. et al. (2025) Cell 188, 4530-4548.e25. PMID: 40446798
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-ARRB1 Polyclonal Antibody

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