

| Numéro de catalogue | VK023014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-ASFV D117L Polyclonal Antibody (VK023014) is a rabbit polyclonal antibody detecting ASFV D117L in ELISA, IHC, WB.
Highlights
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| Reactivité des espèces | African swine fever virus (ASFV) | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant ASFV D117L (Asp2-Thr38&Tyr60-Ser117). | ||||||||
| Cible | Minor capsid protein p17 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q89424 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Minor capsid protein p17 is a ~13 kDa protein. Together with the penton and the other minor capsid proteins (M1249L, p49), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid. Three copies of p17 encircle each p72 capsomer in the inner capsid shell, anchoring p72 capsomers on the inner membrane. Required for the assembly of the capsid and icosahedral morphogenesis. Additionally, inhibits the host cGAS-STING pathway through its interaction with STING1 and subsequent interference of the recruitment of downstream components TBK1 and IKBKE. 1. Wang, N. et al. (2019) Science (New York, N.Y.) 366, 640-644. PMID: 31624094 2. Suárez, C. et al. (2010) Journal of virology 84, 7484-99. PMID: 20504920 3. Zheng, W. et al. (2022) Frontiers in immunology 13, 941579. PMID: 35844609 | ||||||||
| Note | For research use only |

Lane 1: recombinant ASFV D117L (Catalog No: VK023012)
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