

| Número de catálogo | VK776014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-ASFV pM1249L Polyclonal Antibody (VK776014) is a rabbit polyclonal antibody detecting pM1249L in ELISA, IHC, WB.
Highlights
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| Reactividad de especies | African swine fever virus (ASFV) | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant ASFV pM1249L (Gln346-Pro452). | ||||||||
| Objetivo | Minor capsid protein M1249L, pM1249L, Ba71V-060, M1249L | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q65152 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Minor capsid protein M1249L (pM1249L) is a ~144 kDa protein. Together with the penton and the other minor capsid proteins (p17, p49), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid. In addition, blocks IFN-beta transactivation mediated by the cGAS-STING pathway and regulates the transcriptional activity of IFN-beta. Mechanistically, suppresses the phosphorylation of host key adapter protein TBK1 and degrades host IRF3 in the cytoplasm. 1. Wang, N. et al. (2019) Science (New York, N.Y.) 366, 640-644. PMID: 31624094 2. Cui, S. et al. (2022) Virus research 319, 198872. PMID: 35853521 | ||||||||
| Nota | For research use only. |
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