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| カタログ番号 | VK573014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ASFV S273R Polyclonal Antibody (VK573014) is a rabbit polyclonal antibody detecting S273R in ELISA, IHC, WB.
Highlights
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| 種反応性 | African swine fever virus (ASFV) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant ASFV S273R (Met1-Ala273). | ||||||||
| ターゲット | Cysteine protease S273R, pS273R, 3.4.22.-, Ba71V-111, S273R | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q00946 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cysteine protease S273R is a ~31 kDa protein. Cysteine protease that plays several role during infection including processing of the structural polyprotein or inhibition of the host immune response. Catalyzes the maturation of the pp220 and pp62 polyprotein precursors into core-shell proteins. Plays a role in the disruption of host pyroptosis via specific cleavage of gasdermin D/GSDMD. In addition, strongly decreases the host cGAS-STING signaling by targeting IKBKE via its enzymatic activity. Also impairs host FOXJ1-mediated antiviral effect via degradation of FOXJ1. 1. Andrés, G. et al. (2002) Journal of virology 76, 12473-82. PMID: 12438573 2. Zhao, G. et al. (2022) The Journal of biological chemistry 298, 101480. PMID: 34890644 3. Luo, J. et al. (2022) Virulence 13, 740-756. PMID: 35437104 4. Ma, C. et al. (2022) Virologica Sinica 37, 445-454. PMID: 35513267 5. Li, T. et al. (2023) The Journal of biological chemistry 299, 104844. PMID: 37209818 6. Li, YH. et al. (2023) Journal of virology 97, e0194222. PMID: 36856422 | ||||||||
| 注意事項 | For research use only. |
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