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| カタログ番号 | HB362014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ATF7IP Polyclonal Antibody (HB362014) is a rabbit polyclonal antibody detecting Activating transcription factor 7-interacting protein 1; ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621; ATF7IP; MCAF; MCAF1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Chicken.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human ATF7IP (Gln1149-Ser1270). | ||||||||
| ターゲット | Activating transcription factor 7-interacting protein 1; ATF-interacting protein; ATF-IP; ATF7-interacting protein; ATFa-associated modulator; hAM; MBD1-containing chromatin-associated factor 1; P621; ATF7IP; MCAF; MCAF1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6VMQ6, Q7TT18, Q5ZIE8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Activating transcription factor 7-interacting protein 1 (ATF7IP) is a ~136 kDa protein. Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). 1. Timms, RT. et al. (2016) Cell reports 17, 653-659. PMID: 27732843 2. Fujita, N. et al. (2003) Molecular and cellular biology 23, 2834-43. PMID: 12665582 3. Wang, H. et al. (2003) Molecular cell 12, 475-87. PMID: 14536086 4. Liu, L. et al. (2009) The Journal of biological chemistry 284, 5165-74. PMID: 19106100 | ||||||||
| 注意事項 | For research use only |
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