Anti-ATP11A Polyclonal Antibody (HB310014)

Name: Anti-ATP11A Polyclonal Antibody
Brand: abinScience
SKU: HB310014
Price: 168 USD
Availability: InStock

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100ug

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Каталожный номер

HB310014

Описание

Anti-ATP11A Polyclonal Antibody (HB310014) is a rabbit polyclonal antibody detecting Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human ATP11A (Asp387-Lys860).

Цель

Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

P98196, P98197

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Phospholipid-transporting ATPase IH (ATP11A) is a ~129 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Does not show flippase activity toward phosphatidylcholine (PC). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

1. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773

2. Naito, T. et al. (2015) The Journal of biological chemistry 290, 15004-17. PMID: 25947375

3. Segawa, K. et al. (2016) The Journal of biological chemistry 291, 762-72. PMID: 26567335

4. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007

5. Wang, J. et al. (2018) Scientific reports 8, 10795. PMID: 30018401

6. Chepurwar, S. et al. (2023) Human molecular genetics 32, 1083-1089. PMID: 36300302

7. Segawa, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34403372

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-ATP11A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-ATP11A Polyclonal Antibody (HB310014)

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