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| カタログ番号 | HB179014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ATP2A2 Polyclonal Antibody (HB179014) is a rabbit polyclonal antibody detecting ATP2A2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATP2A2 (Ile315-Met756). | ||||||||
| ターゲット | SERCA2, Calcium pump 2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATP2B, SR Ca(2+)-ATPase 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, ATP2A2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P16615 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) is a ~114 kDa protein. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis. 1. Dhitavat, J. et al. (2003) The Journal of investigative dermatology 120, 229-32. PMID: 12542527 2. Dally, S. et al. (2006) The Biochemical journal 395, 249-58. PMID: 16402920 3. Zhao, YG. et al. (2017) Molecular cell 67, 974-989.e6. PMID: 28890335 | ||||||||
| 注意事項 | For research use only. |
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