

| Каталожный номер | HB179014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-ATP2A2 Polyclonal Antibody (HB179014) is a rabbit polyclonal antibody detecting ATP2A2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human ATP2A2 (Ile315-Met756). | ||||||||
| Цель | SERCA2, Calcium pump 2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATP2B, SR Ca(2+)-ATPase 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, ATP2A2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P16615 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) is a ~114 kDa protein. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis. 1. Dhitavat, J. et al. (2003) The Journal of investigative dermatology 120, 229-32. PMID: 12542527 2. Dally, S. et al. (2006) The Biochemical journal 395, 249-58. PMID: 16402920 3. Zhao, YG. et al. (2017) Molecular cell 67, 974-989.e6. PMID: 28890335 | ||||||||
| Примечание | For research use only. |
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