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| カタログ番号 | HX191014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ATP2C1 Polyclonal Antibody (HX191014) is a rabbit polyclonal antibody detecting ATP2C1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ATP2C1 (Val313-Ile699). | ||||||||
| ターゲット | Calcium-transporting ATPase type 2C member 1, ATP-dependent Ca(2+) pump PMR1, PMR1L, KIAA1347, ATP2C1, ATPase 2C1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P98194 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Calcium-transporting ATPase type 2C member 1 (ATP2C1) is a ~100 kDa protein. ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity. 1. Fairclough, RJ. et al. (2003) The Journal of biological chemistry 278, 24721-30. PMID: 12707275 2. Dode, L. et al. (2005) The Journal of biological chemistry 280, 39124-34. PMID: 16192278 3. Lissandron, V. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 9198-203. PMID: 20439740 4. Mukhopadhyay, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 858-63. PMID: 21187401 5. Chen, J. et al. (2019) The Journal of biological chemistry 294, 7878-7891. PMID: 30923126 6. Dode, L. et al. (2006) The Journal of biological chemistry 281, 3182-9. PMID: 16332677 7. Behne, MJ. et al. (2003) The Journal of investigative dermatology 121, 688-94. PMID: 14632183 | ||||||||
| 注意事項 | For research use only. |
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