Anti-ATP6AP2 Polyclonal Antibody (HF566014)

Name: Anti-ATP6AP2 Polyclonal Antibody
Brand: abinScience
SKU: HF566014
Price: 168 USD
Availability: InStock

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HF566014

Descripción

Anti-ATP6AP2 Polyclonal Antibody (HF566014) is a rabbit polyclonal antibody detecting ATP6AP2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ATP6AP2 (Asn17-Glu302).

Objetivo

Renin/prorenin receptor, ER-localized type I transmembrane adapter, ATPase H(+)-transporting lysosomal accessory protein 2, CAPER, ATP6M8-9, Embryonic liver differentiation factor 10, ATP6AP2, ATPase H(+)-transporting lysosomal-interacting protein 2, V-ATPase M8.9 subunit, ATP6IP2, Renin receptor, N14F, ELDF10, Vacuolar ATP synthase membrane sector-associated protein M8-9

Purificación

Purified by antigen affinity column.

Número de acceso

O75787

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Renin receptor (ATP6AP2) is a ~39 kDa protein. Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.

1. Nguyen, G. et al. (2002) The Journal of clinical investigation 109, 1417-27. PMID: 12045255

2. Rujano, MA. et al. (2017) The Journal of experimental medicine 214, 3707-3729. PMID: 29127204

3. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053

4. Su, W. et al. (2020) Viruses 12. PMID: 32276428

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-ATP6AP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo