Anti-ATP6AP2 Polyclonal Antibody (HF566014)

Name: Anti-ATP6AP2 Polyclonal Antibody
Brand: abinScience
SKU: HF566014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HF566014

Description

Anti-ATP6AP2 Polyclonal Antibody (HF566014) is a rabbit polyclonal antibody detecting ATP6AP2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ATP6AP2 (Asn17-Glu302).

Cible

Renin/prorenin receptor, ER-localized type I transmembrane adapter, ATPase H(+)-transporting lysosomal accessory protein 2, CAPER, ATP6M8-9, Embryonic liver differentiation factor 10, ATP6AP2, ATPase H(+)-transporting lysosomal-interacting protein 2, V-ATPase M8.9 subunit, ATP6IP2, Renin receptor, N14F, ELDF10, Vacuolar ATP synthase membrane sector-associated protein M8-9

Purification

Purified by antigen affinity column.

Numéro d'accès

O75787

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Renin receptor (ATP6AP2) is a ~39 kDa protein. Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.

1. Nguyen, G. et al. (2002) The Journal of clinical investigation 109, 1417-27. PMID: 12045255

2. Rujano, MA. et al. (2017) The Journal of experimental medicine 214, 3707-3729. PMID: 29127204

3. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053

4. Su, W. et al. (2020) Viruses 12. PMID: 32276428

Note

For research use only.

Images

Reférences

Fiche technique

Anti-ATP6AP2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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