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| カタログ番号 | HT310014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-AZIN1 Polyclonal Antibody (HT310014) is a rabbit polyclonal antibody detecting AZIN1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AZIN1 (Ile5-Lys290). | ||||||||
| ターゲット | AZIN1, OAZIN, AZI1, Antizyme inhibitor 1, OAZI, AZI, Ornithine decarboxylase antizyme inhibitor | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14977 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Antizyme inhibitor 1 (AZIN1) is a ~49 kDa protein. Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. 1. Kanerva, K. et al. (2008) The Biochemical journal 409, 187-92. PMID: 17900240 2. Wu, HY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 11229-34. PMID: 26305948 | ||||||||
| 注意事項 | For research use only. |
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