

| Каталожный номер | HX193014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-BACE1 Polyclonal Antibody (HX193014) is a rabbit polyclonal antibody detecting BACE1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cavia porcellus.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human BACE1 (Glu46-Thr457). | ||||||||
| Цель | BACE1, Memapsin-2, KIAA1149, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, BACE, Beta-site APP cleaving enzyme 1, Beta-secretase 1, Aspartyl protease 2, ASP2, Membrane-associated aspartic protease 2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P56817 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Beta-secretase 1 (BACE1) is a ~55 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1. 1. Hussain, I. et al. (1999) Molecular and cellular neurosciences 14, 419-27. PMID: 10656250 2. Lin, X. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 1456-60. PMID: 10677483 3. Okada, H. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 2783-94. PMID: 20354142 | ||||||||
| Примечание | For research use only. |



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