

| Número de catálogo | HP706014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human BAG5 (Met1-Asp248). | ||||||||
| Objetivo | BAG5, KIAA0873, BAG-5, BAG family molecular chaperone regulator 5, Bcl-2-associated athanogene 5 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q9UL15 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | BAG family molecular chaperone regulator 5 (BAG5) is a ~51 kDa protein. Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. 1. Arakawa, A. et al. (2010) Structure (London, England : 1993) 18, 309-19. PMID: 20223214 | ||||||||
| Nota | For research use only. |
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