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Anti-BCAR3 Polyclonal Antibody (HF517014)

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Vista general
Número de catálogoHF517014
Descripción
Anti-BCAR3 Polyclonal Antibody (HF517014) is a rabbit polyclonal antibody detecting BCAR3 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human BCAR3 (Glu533-Leu825).
Objetivo SH2 domain-containing protein 3B, Novel SH2-containing protein 2, SH2D3B, NSP2, Breast cancer anti-estrogen resistance protein 3, BCAR3
Purificación Purified by antigen affinity column.
Número de acceso O75815
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Breast cancer anti-estrogen resistance protein 3 (BCAR3) is a ~92 kDa protein. Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity.

1. Oh, MJ. et al. (2013) Biochemical and biophysical research communications 441, 911-6. PMID: 24216110
2. Rufanova, VA. et al. (2009) Journal of cellular physiology 219, 45-56. PMID: 19086031
3. Oh, MJ. et al. (2008) Biochemical and biophysical research communications 375, 430-4. PMID: 18722344
4. Mace, PD. et al. (2011) Nature structural & molecular biology 18, 1381-7. PMID: 22081014
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-BCAR3 Polyclonal Antibody

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